Brain-wide neuronal circuit connectome of human glioblastoma
Adult Neurogenesis
How newborn neurons in the adult hippocampus integrate into existing circuits — and why this declines with age.
Axon Guidance
Molecular and cellular mechanisms that direct axons to their correct targets during development and throughout life.
Brain Aging
How aging alters the formation, maturation, and synaptic connectivity of hippocampal newborn neurons.
Our lab is located at the Institute of Molecular Biology (IMB), Academia Sinica, Taipei, Taiwan. We combine mouse genetics, confocal and electron microscopy, array tomography, and C. elegans genetics to investigate how the brain builds its neural circuits and how this capacity changes across the lifespan.
Led by Dr. Hwai-Jong Cheng (Distinguished Research Fellow and Director of IMB), the lab has made foundational contributions to axon guidance, including the identification of ephrins as topographic map molecules and the in vivo roles of semaphorin–plexin signaling in axon pruning.